In a commanding performance, the Denver Broncos secured a 35-17 victory over the San Francisco 49ers in Week 1 of the 2028 season. This matchup set the tone for both teams as they look to establish themselves early in the season, but it was the Broncos who came out swinging and showcased their offensive prowess. Bo Nix led the charge for Denver, throwing for an impressive 328 yards and four touchdowns, proving to be a formidable force behind center. Jaylen Waddle was a reliable target, racking up 91 receiving yards and contributing significantly to the passing attack. Meanwhile, Christian McCaffrey was the standout for the 49ers, accumulating 81 rushing yards, but it wasn't enough to keep pace with the Broncos' high-octane offense. Defensively, the Broncos made their mark with Myles Graham leading the way with nine total tackles, while Nik Bonitto added pressure with two sacks and Riley Moss secured an interception. The turning point of the game came when Moss picked off a crucial pass in the second quarter, shifting momentum firmly in Denver's favor and allowing them to maintain control throughout the contest.