The San Francisco 49ers delivered a commanding performance, defeating the Arizona Cardinals 48-10 in Week 12 of the 2027 season. With playoff implications on the line, the 49ers showcased their dominance on both sides of the ball, solidifying their position as a contender in the conference. Brock Purdy was the standout on offense, throwing for 157 yards and two touchdowns, while Trey Benson added a powerful ground game with 119 rushing yards. The 49ers' offense was efficient, capitalizing on opportunities and maintaining control throughout the contest. On the other side, Dont'e Thornton Jr. stood out for the Cardinals with 77 receiving yards, but the team struggled to find consistency. Defensively, the 49ers were relentless, led by Deommodore Lenoir, who recorded three interceptions, completely swinging the momentum in San Francisco's favor. Clay Matthews also contributed with two sacks, applying constant pressure on the Cardinals' quarterback. The turning point came in the second quarter when Lenoir's first interception set up a quick touchdown, allowing the 49ers to pull away and never look back.