In a decisive Week 4 matchup, the San Francisco 49ers topped the Denver Broncos with a final score of 37-16, solidifying their position in the playoff race early in the 2026 season. The 49ers showcased their offensive prowess, dominating the game and keeping the Broncos at bay throughout. Brock Purdy led the charge for San Francisco, throwing for four touchdowns and making crucial plays that kept the Broncos defense on their heels. De'Zhaun Stribling was a standout receiver, racking up an impressive 142 receiving yards, while Christian McCaffrey added valuable ground support with 49 rushing yards. Bo Nix put up a valiant effort for the Broncos, finishing with 291 passing yards, but it wasn't enough to keep pace with the 49ers' explosive offense. Defensively, the 49ers were relentless, highlighted by Nick Bosa's three sacks that disrupted Denver's rhythm and forced critical mistakes. Ephesians Prysock led the team in tackles, helping to stifle any momentum the Broncos attempted to build. The turning point came in the second quarter when Purdy threw his third touchdown, stretching the lead to 24-10 and putting the Broncos in a difficult position from which they couldn’t recover.