In a thrilling Week 3 matchup of the 2026 season, the San Francisco 49ers topped the Arizona Cardinals with a final score of 42-28. With both teams looking to solidify their standings, the 49ers emerged victorious, showcasing their offensive firepower and defensive resilience. Brock Purdy led the charge for San Francisco with an impressive 306 passing yards, while tight end George Kittle delivered a standout performance, racking up 134 receiving yards. For Arizona, Carson Beck had a remarkable game, tossing four touchdown passes to keep the Cardinals competitive despite the loss. Jeremiyah Love contributed on the ground for Arizona, adding 62 rushing yards to the team's efforts. Defensively, the 49ers made crucial plays that swung momentum in their favor. Fred Warner anchored the defense with six total tackles, while Amare Barno was a force on the pass rush, recording three sacks. The game's turning point came in the second quarter when San Francisco's defense stifled a Cardinals drive, leading to a quick touchdown that shifted the momentum decisively toward the 49ers.