In a commanding display, the San Francisco 49ers topped the Seattle Seahawks 42-21 in Week 5 of the 2026 season. This victory not only boosts the 49ers' momentum but also solidifies their position in the playoff race, showcasing their offensive firepower against a division rival. Brock Purdy led the charge for San Francisco, throwing for 259 yards and three touchdowns, effectively orchestrating the offense throughout the game. Running back Christian McCaffrey complemented the passing game with a stellar performance on the ground, racking up 139 rushing yards. Deebo Samuel Sr. was the primary target for Purdy, amassing 130 receiving yards, as the 49ers demonstrated an impressive balance between the run and pass. While the Seahawks struggled to contain the 49ers' offensive onslaught, their defense had moments of resilience, led by Ernest Jones IV, who made ten total tackles. The turning point came in the second quarter when a critical interception by Nick Emmanwori gave Seattle a glimmer of hope, but San Francisco quickly responded, maintaining control and ultimately pulling away for the decisive win.