In a high-octane showdown, the San Francisco 49ers topped the Denver Broncos 49-24 in Week 4 of the 2026 season. With both teams looking to establish momentum early in the season, the 49ers proved to be the dominant force, showcasing their offensive firepower and solidifying their place in the playoff conversation. Brock Purdy was the star of the night, throwing for 281 yards and four touchdowns, demonstrating precision and poise in the pocket. Christian McCaffrey was a force on the ground, racking up 164 rushing yards and providing a consistent threat to the Broncos' defense. De'Zhaun Stribling contributed significantly in the passing game, leading all receivers with 99 yards, further amplifying the 49ers' offensive onslaught. Defensively, the 49ers made key plays that shifted the momentum of the game, highlighted by Malik Mustapha's interception that halted a potential Broncos scoring drive. Ji'Ayir Brown led the charge with five total tackles, keeping Denver’s offensive efforts in check. The turning point came in the second quarter, where the combination of Purdy's scoring and the defense's timely stops allowed San Francisco to build an insurmountable lead that Denver simply couldn't overcome.