In a closely contested matchup, the San Francisco 49ers topped the Detroit Lions 28-22 in Week 10 of the 2027 season. This victory was crucial for the 49ers as they aim to solidify their playoff position, while the Lions fought hard to stay in the race for a Wild Card spot. Brock Purdy led the charge for San Francisco, throwing for 332 yards and two touchdowns, showcasing his ability to connect with his receivers under pressure. Ricky Pearsall emerged as a standout target, racking up 103 receiving yards, while Christian McCaffrey contributed significantly on the ground with 72 rushing yards, helping to keep the Lions' defense on its heels. Defensively, San Francisco's Marshon Lattimore made a pivotal play with an interception that shifted momentum in the second half. Although Detroit's Jack Campbell recorded 10 tackles and Aidan Hutchinson added a sack, the Lions struggled to contain the 49ers' offensive rhythm, ultimately leading to their defeat. The game turned when Lattimore's pick set up a crucial touchdown, allowing the 49ers to maintain their lead and secure the win.