In a tightly contested matchup, the San Francisco 49ers held off the Arizona Cardinals with a final score of 24-18 in Week 16 of the 2027 season. With playoff implications on the line, the 49ers secured a critical victory that keeps their postseason hopes alive. Joe Milton showcased his passing prowess for the Cardinals, racking up 382 passing yards and tossing two touchdowns, but it wasn’t enough to clinch the win. Meanwhile, Christian McCaffrey led the charge for San Francisco with 113 rushing yards, adding balance to their offensive attack. Marvin Harrison Jr. also made a significant impact for Arizona, accumulating 155 receiving yards, highlighting the competitive nature of the game. Defensively, the 49ers made key plays that shifted momentum, particularly Myles Garrett's 1.5 sacks and Renardo Green’s interception. The turning point came late in the fourth quarter when Green picked off a critical pass, stifling the Cardinals' comeback attempt and allowing San Francisco to run down the clock. Will Johnson led the Cardinals' defense with nine tackles, but it was the 49ers' timely defensive stands that ultimately sealed the victory.