In a tightly contested matchup, the Detroit Lions topped the Buffalo Bills 28-20 in Week 2 of the 2026 season. Both teams were looking to establish momentum early in the season, but it was the Lions who emerged victorious, showcasing their offensive prowess. Jared Goff led the charge for Detroit, throwing for 270 yards and three touchdowns, proving to be a decisive factor in the Lions' success. Amon-Ra St. Brown was his favorite target, racking up 101 receiving yards, while the Lions' offense consistently found ways to exploit the Bills' defense. Defensively, the Lions made pivotal plays to secure their win, including a crucial interception by Jack Campbell that shifted momentum in the second half. While the Bills' Christian Benford tallied eight total tackles and Greg Rousseau registered 1.5 sacks, it was the Lions' ability to make key stops and capitalize on turnovers that ultimately determined the outcome of the game.