In a tightly contested matchup, the Arizona Cardinals defeated the Los Angeles Rams 17-10 in Week 6 of the 2026 season. Both teams were looking to solidify their positions in the playoff race, but it was the Cardinals who emerged victorious, showcasing their resilience in a critical division battle. Arizona's Michael Penix Jr. led the way with an impressive performance, throwing for 272 yards, while Christian Watson was his go-to target, racking up 131 receiving yards. The Rams' Trevor Lawrence managed to toss one touchdown, but it was Josh Jacobs’ 85 rushing yards that kept Los Angeles competitive throughout the game. Defensively, the Cardinals were formidable, with Quay Walker leading the charge with 11 tackles and Will Anderson Jr. contributing a crucial sack. The turning point came late in the fourth quarter when the Rams were driving for a potential game-tying touchdown, but a key interception by Dre Greenlaw halted their momentum, sealing the victory for Arizona.