In a decisive Week 3 matchup, the Arizona Cardinals topped the San Francisco 49ers with a final score of 35-18. The Cardinals' victory solidifies their position early in the season, while the 49ers will need to regroup after this setback to stay competitive in the division. Michael Penix Jr. led the Cardinals' offense with two touchdown passes, showcasing his ability to connect with playmakers downfield. Meanwhile, Jacory Croskey-Merritt contributed significantly on the ground, rushing for 70 yards and providing a balanced attack. Dak Prescott put up impressive numbers for the 49ers, throwing for 264 yards, but it wasn’t enough to secure a win. Defensively, the Cardinals were relentless, with Nick Cross making a game-changing impact by intercepting two passes, which shifted momentum in Arizona’s favor. Quan Martin led the team with six total tackles, helping to contain the 49ers' offensive efforts. The turning point came late in the second quarter when Cross's second interception set up a crucial touchdown that extended the Cardinals' lead, ultimately sealing San Francisco's fate.