The Denver Broncos topped the San Francisco 49ers with a final score of 21-10 in Week 4 of the 2026 season, securing a crucial victory that bolsters their playoff aspirations. The Broncos showcased their offensive prowess, with Bo Nix leading the charge and delivering a standout performance under center. Nix threw for 186 yards and tossed two touchdown passes, effectively guiding Denver’s passing attack. Meanwhile, Jaylen Waddle was a force in the receiving game, racking up 109 yards, while Jaydon Blue contributed on the ground with 48 rushing yards, providing balance to the offense. Defensively, the Broncos made their presence felt, particularly with Tycen Anderson’s two interceptions that halted any momentum the 49ers attempted to build. Nik Bonitto added pressure with a key sack that disrupted San Francisco's rhythm, and it was his defensive standout plays that shifted the momentum in favor of the Broncos. Overall, Denver's defense played a vital role in sealing this important win.