In a decisive victory, the Arizona Cardinals topped the San Francisco 49ers 24-10 in Week 3 of the 2026 season. This win solidifies the Cardinals' early-season momentum and places them firmly in playoff contention, while the 49ers will need to regroup to keep their hopes alive. Carson Beck led the Cardinals' offense with a stellar performance, throwing for 280 yards and three touchdowns, showcasing his growing chemistry with wide receiver Devaughn Vele, who racked up 128 receiving yards. The duo consistently connected, putting pressure on the 49ers' defense and helping to establish a commanding lead. Defensively, the Cardinals were bolstered by Walter Nolen III, who recorded 1.5 sacks, disrupting the 49ers' offensive rhythm. The turning point came in the second quarter when Beck's third touchdown pass extended the lead to 21-3, forcing San Francisco to abandon their game plan and play catch-up. Despite Ephesians Prysock's 11 tackles for the 49ers, the Cardinals' defense held firm, securing the win with a strong showing throughout the game.