In a decisive Week 2 matchup of the 2026 season, the Detroit Lions topped the Buffalo Bills with a final score of 21-6. With this victory, the Lions solidified their position early in the season, showcasing their offensive prowess and defensive strength against a struggling Bills squad. Jared Goff led the charge for the Lions, throwing for 213 yards and two touchdowns, effectively orchestrating the offense. Isaac TeSlaa emerged as his favorite target, racking up an impressive 98 receiving yards, while Jahmyr Gibbs contributed on the ground with 42 rushing yards. This combination of aerial and ground attacks proved too much for the Bills to handle. Defensively, the Lions made their presence felt, spearheaded by Derrick Moore's two sacks that disrupted the Bills' offensive rhythm. The turning point came in the second quarter when Goff connected with TeSlaa for a crucial touchdown, extending the Lions' lead and putting pressure on Buffalo to respond. While Jordan Hancock tallied four tackles for the Bills, it wasn't enough to shift the momentum as Detroit's defense held firm, limiting Buffalo to just two field goals.