In a commanding performance, the San Francisco 49ers took down the Washington Commanders with a final score of 49-14 in Week 6 of the 2026 season. This victory solidifies the 49ers' position as a strong contender in the league, while the Commanders will need to regroup after this heavy defeat. Brock Purdy led the charge for San Francisco, throwing for 330 yards and three touchdowns, showcasing his ability to command the offense effectively. Christian McCaffrey added to the onslaught with 108 rushing yards, while De'Zhaun Stribling caught fire in the receiving game, racking up 148 yards, proving to be a reliable target downfield. On the defensive side, the 49ers were bolstered by Kerby Joseph's interception, which shifted momentum in their favor and helped stifle Washington's attempts at a comeback. The turning point came early in the second quarter when the 49ers scored back-to-back touchdowns, creating an insurmountable lead that the Commanders struggled to overcome throughout the game.