In a commanding performance, the Buffalo Bills toppled the Los Angeles Chargers with a final score of 45-24, improving their record to 2-1 in the early weeks of the 2026 season. This victory not only showcased the Bills' offensive prowess but also solidified their position as a contender in the league. Josh Allen was outstanding under center for Buffalo, tossing four touchdown passes and leading his team with precision. James Cook III complemented the passing attack with a stellar 111 rushing yards, consistently finding gaps in the Chargers' defense. On the other side, Justin Herbert put up solid numbers with 255 passing yards, but the Chargers struggled to keep pace with the high-octane Bills offense. Defensively, the Bills were relentless, highlighted by Quinn Talen's two crucial interceptions that shifted momentum in Buffalo's favor. Greg Rousseau added pressure with a sack, while the defense as a whole limited the Chargers' opportunities to mount a comeback. The turning point came in the second quarter, when Talen's first interception set up a quick touchdown, allowing the Bills to pull away and maintain control throughout the game.