In a decisive matchup, the Indianapolis Colts topped the Tennessee Titans 42-21 in Week 15 of the 2026 season. With playoff aspirations on the line, the Colts delivered a commanding performance, securing their position in the postseason race while the Titans faced a significant setback. Indianapolis quarterback Anthony Richardson Sr. was in peak form, throwing for five touchdowns and showcasing his ability to lead the offense effectively. Meanwhile, running back Jonathan Taylor racked up 133 rushing yards, complementing the aerial assault. Keenan Allen emerged as Richardson's favorite target, amassing an impressive 198 receiving yards, proving to be a constant threat to the Titans' secondary. Defensively, the Colts made crucial plays that shifted the momentum of the game. DeForest Buckner recorded two sacks, pressuring Titans quarterback Cam Ward, who still managed to throw for 383 yards but was unable to find the end zone consistently. A pivotal moment came when Jessie Bates III intercepted a pass, halting a potential Titans scoring drive and allowing the Colts to extend their lead, ultimately sealing the game.