The Detroit Lions turned a Week 2 road trip into a statement, burying the Buffalo Bills 55-17 in Orchard Park. Detroit never let the game breathe, piling up points in every phase of the offense and leaving Buffalo searching for answers before halftime. For a Bills team hoping to establish itself early in the 2026 season, this was the kind of afternoon that lingers. Jared Goff was surgical, throwing for 394 yards and four touchdowns while dictating terms from the pocket. His favorite target needed no introduction: Amon-Ra St. Brown torched Buffalo for 201 receiving yards, repeatedly finding space over the middle and turning short throws into chunk gains. Jahmyr Gibbs added 78 yards on the ground, giving the Lions just enough balance to keep the Bills' front honest. By the time Detroit's starters gave way, the offense had produced 55 points and dictated the game's rhythm from the opening drive. Defensively, the Lions made life miserable for Buffalo, with Kaiir Elam's interception the swing play that flipped a competitive stretch into a rout. Aidan Hutchinson's half-sack was part of steady pressure that kept the Bills from stringing together sustained drives. On the other side, C.J. Gardner-Johnson led all players with 10 tackles — a stat line that told the story of how often Buffalo's defense was on the field. Once Detroit converted the takeaway into points, the outcome was never in question.