The Indianapolis Colts dominated the Washington Commanders with a resounding 41-10 victory in Week 4 of the 2026 season. This win solidifies the Colts' position as a formidable contender in the league, while the Commanders will need to regroup after a tough matchup at home. Quarterback Patrick Mahomes led the Colts' offensive charge, throwing for 242 yards and three touchdowns, showcasing his elite playmaking ability. Running back Kyren Williams added a powerful ground game with 124 rushing yards, while wide receiver Michael Wilson was a standout target, racking up 151 receiving yards. The Colts' offense was efficient and explosive, leaving the Commanders struggling to keep pace. On the defensive side, Ed Oliver made his presence felt with a key sack, helping to disrupt Washington's offensive rhythm. Although the Commanders' Jaylon Johnson recorded a solid six total tackles, the Colts' defense was able to limit scoring opportunities and control the game. The turning point came early in the second half when Mahomes connected with Wilson for a touchdown, extending the lead to 28-3 and putting the game out of reach for Washington.