In a commanding performance, the Arizona Cardinals topped the San Francisco 49ers 35-6 in Week 3 of the 2026 season. With this victory, the Cardinals solidified their position as a strong contender in the league, showcasing their offensive firepower against a struggling 49ers squad. Jalen Hurts was the standout for Arizona, throwing for an impressive 372 yards and three touchdowns, demonstrating his elite passing ability. He connected frequently with T.J. Hockenson, who racked up 134 receiving yards, making big plays that kept the 49ers' defense on their heels. Meanwhile, San Francisco's Jonathan Taylor put forth a respectable effort on the ground with 105 rushing yards, but it was not enough to keep pace with the Cardinals' offensive onslaught. Defensively, the Cardinals were relentless, led by Kaden Elliss, who recorded two sacks, putting constant pressure on the 49ers' quarterback. The turning point came in the second quarter when Cor'Dale Flott intercepted a pass, setting up another quick touchdown for Arizona that pushed the lead to an insurmountable margin. The 49ers struggled to respond, and the Cardinals' defense continued to clamp down, sealing a dominant victory.