In a commanding display, the San Francisco 49ers topped the Kansas City Chiefs 42-10 in Week 16 of the 2026 season. With playoff positioning on the line, the 49ers delivered a decisive victory that showcased their offensive prowess and defensive strength. Brock Purdy was the star of the night, throwing for 378 yards and four touchdowns, leading the 49ers' air assault. Deebo Samuel Sr. was his primary target, racking up an impressive 190 receiving yards, while Kaelon Black contributed solidly on the ground with 76 rushing yards. The offensive firepower of the 49ers was simply too much for the Chiefs to handle. Defensively, the Chiefs struggled to contain the 49ers' offensive onslaught, despite Alohi Gilman leading his team with eight total tackles. San Francisco's ability to consistently find the end zone shifted the momentum early in the game, with their fourth touchdown effectively sealing the fate of the Chiefs. Kansas City’s lone bright spot came from R Mason Thomas, who recorded a sack, but it was not enough to change the outcome of this lopsided affair.