In a dominating performance, the Arizona Cardinals cruised to a 55-17 victory over the San Francisco 49ers in Week 3 of the 2026 season. With this win, the Cardinals solidified their position as a serious contender in the league, showcasing their offensive firepower against a struggling 49ers team. Quarterback J.J. McCarthy had a standout game, throwing for an impressive 342 yards and five touchdowns, displaying both precision and power throughout the contest. Marvin Harrison Jr. emerged as his favorite target, racking up 189 receiving yards, while James Conner contributed on the ground with 76 rushing yards, helping the offense maintain a relentless pace. Defensively, the Cardinals were equally impactful, with Josh Sweat leading the charge, registering 1.5 sacks that disrupted the 49ers' offensive flow. The turning point came early in the second half when McCarthy connected with Harrison for a touchdown that extended the lead to 21 points, leaving the 49ers unable to recover. Overall, the Cardinals' ability to dominate both sides of the ball was key to their impressive victory.