In an action-packed showdown, the Arizona Cardinals topped the St. Louis Rams with a final score of 52-38 in Week 6 of the 2026 season, showcasing their offensive firepower in a critical matchup. The Cardinals demonstrated their capability to score at will, solidifying their position as contenders in the league. Leading the charge for Arizona was quarterback Matt Leinart, who threw for an impressive 406 yards and found the end zone multiple times. Running back Edgerrin James also made a significant impact, racking up 141 rushing yards to complement the aerial attack. On the other side, Rams quarterback Marc Bulger kept pace with four touchdown passes, while Kevin Curtis delivered a standout performance with 180 receiving yards. The defensive efforts played a crucial role in the outcome, particularly with the Cardinals' Aaron Francisco making a game-changing impact with two interceptions. Despite the Rams' Leonard Little recording three sacks and Corey Chavous leading with five tackles, it was Arizona's ability to capitalize on key turnovers that ultimately shifted momentum. The turning point came late in the game when Francisco's second pick set up a crucial touchdown, allowing the Cardinals to pull ahead decisively.