In a commanding performance, the Detroit Lions topped the Buffalo Bills with a final score of 34-10, securing their second win of the season. The Lions aimed to assert their dominance early in the 2026 campaign, and they did just that against a struggling Bills team. Leading the charge for Detroit was quarterback Joe Milton, who threw for 124 yards and two touchdowns. Running back Jahmyr Gibbs was a force on the ground, racking up an impressive 149 rushing yards, showcasing both speed and agility. Despite the loss, Khalil Shakir of the Bills made a notable impact with 85 receiving yards, but it wasn't enough to keep pace with the Lions’ offensive onslaught. Defensively, the Lions were opportunistic, with Justin Reid snagging an interception that shifted momentum in favor of Detroit. The turning point came in the second quarter when Reid's pick set up a touchdown drive, extending the Lions' lead to 21-3. The Bills struggled to recover from that blow, as Detroit continued to dominate throughout the game.