In a dominant performance, the Detroit Lions defeated the Buffalo Bills 45-17 in Week 2 of the 2026 season. With this victory, the Lions not only secured their place in the early playoff conversation but also showcased their offensive firepower against a struggling Bills team. Malik Willis led the charge for Detroit, throwing for 253 yards and two touchdowns, effectively orchestrating the offense throughout the game. Chase Brown was a key contributor on the ground, racking up 136 rushing yards and keeping the Bills' defense on their heels. Meanwhile, Chimere Dike emerged as the brightest spot for Buffalo, finishing with 98 receiving yards, but it wasn’t enough to keep pace with the Lions' offensive explosion. The Lions' defense played a pivotal role in the outcome, highlighted by Troy Andersen's two interceptions that shifted the momentum firmly in Detroit's favor. The turning point came when Andersen picked off a pass in the third quarter, setting up a quick touchdown that extended the Lions' lead and left the Bills struggling to respond. Overall, the Lions' ability to capitalize on turnovers and maintain offensive efficiency secured their commanding victory.