In a dominant performance, the San Francisco 49ers defeated the Denver Broncos 45-10 in Week 4 of the 2026 season. With this victory, the 49ers continue to solidify their position as contenders, showcasing their offensive prowess against a struggling Broncos squad. Bo Nix led the charge for San Francisco, throwing for 246 yards and two touchdowns, demonstrating precision and poise throughout the game. Chuba Hubbard added a solid ground game with 72 rushing yards, contributing to the team's balanced offensive attack. Meanwhile, Drake London stood out for Denver, posting 87 receiving yards in a losing effort. Defensively, the 49ers were a force to be reckoned with, highlighted by Cooper DeJean’s two interceptions, which shifted the momentum firmly in San Francisco's favor. Taylor Rapp's ten tackles showcased the team's ability to stifle the Broncos' offensive attempts. The turning point came early in the second half when DeJean's second interception set up a quick touchdown, effectively putting the game out of reach for Denver.