In a high-octane matchup, the Detroit Lions triumphed over the Buffalo Bills with a stunning final score of 69-34, marking a decisive victory in Week 2 of the 2026 season. Both teams were looking to solidify their early-season standings, but the Lions showcased their offensive firepower, leaving the Bills struggling to keep pace. Baker Mayfield put on an impressive display for the Bills, racking up 425 passing yards and throwing four touchdown passes. However, it was Barry Sanders who stole the show with a jaw-dropping 415 rushing yards for the Lions, dominating the ground game and keeping the Buffalo defense on its heels. Kyle Pitts Sr. also had a solid outing for the Bills, totaling 163 receiving yards, but it wasn’t enough to overcome Detroit's explosive attack. On the defensive side, the Lions made pivotal plays that turned the tide of the game. Nick Cross led the defense with seven total tackles, while Caleb Ransaw's interception added to the chaos for the Bills’ offense. The turning point came when Detroit's defense stifled a key drive from Buffalo, allowing the Lions to capitalize and extend their lead, ultimately sealing the game with authority.