In a tightly contested battle, the San Francisco 49ers narrowly defeated the Arizona Cardinals 27-24 in Week 3 of the 2026 season. With both teams vying for early-season momentum, the stakes were high as the 49ers aimed to solidify their place in the standings against a fierce divisional rival. Brock Purdy led the charge for San Francisco, throwing for 258 yards and managing the game effectively. Meanwhile, Carson Beck kept the Cardinals competitive with two touchdown passes, showcasing his ability to respond to pressure. Christian McCaffrey was the standout on the ground, dominating the rushing attack with 130 yards, while De'Zhaun Stribling provided a reliable target with 84 receiving yards. The 49ers' defense played a crucial role in the victory, particularly in the game's decisive moments. Although the Cardinals had their opportunities, San Francisco's ability to hold off the late-game surge proved vital. Arizona's Mack Wilson Sr. recorded four tackles, but it was the 49ers' consistent pressure and strategic stops that ultimately sealed the win, marking an important early-season triumph for San Francisco.