In a commanding performance, the Denver Broncos defeated the San Francisco 49ers 45-17 in Week 4 of the 2026 season. The Broncos showcased their dominance, solidifying their position as a formidable contender in the league while handing the 49ers a tough loss on their home turf. Bo Nix led the charge for Denver, throwing for an impressive 369 yards and five touchdowns, showcasing his elite passing ability. Troy Franklin was his favorite target, racking up 153 receiving yards and contributing significantly to the offensive explosion. Meanwhile, Christian McCaffrey was the lone bright spot for San Francisco, managing just 58 rushing yards in a game where the 49ers struggled to find their rhythm. Defensively, the Broncos were relentless, with Devin Lloyd leading the team with six total tackles. Nik Bonitto made his presence felt with two sacks, consistently putting pressure on the 49ers' offense. The game's turning point came early in the second quarter when Brandon Jones intercepted a pass, setting the tone for Denver's dominant defensive display and allowing them to maintain control throughout the contest.