In a commanding performance, the San Francisco 49ers topped the Arizona Cardinals 35-14 in Week 3 of the 2026 season. With both teams looking to establish momentum early in the season, the 49ers proved they are a force to be reckoned with in the NFC West. Brock Purdy led the charge for San Francisco, throwing for 251 yards and three touchdowns, showcasing his ability to connect with his targets effectively. George Kittle was the standout receiver, racking up an impressive 144 receiving yards, while Christian McCaffrey contributed on the ground with 59 rushing yards, helping to keep the Cardinals' defense on its heels. Defensively, the 49ers made their mark by forcing turnovers and applying pressure. Fred Warner's interception shifted momentum in the game, while Zaven Collins of the Cardinals recorded two sacks, but it wasn't enough to deter San Francisco. The turning point came midway through the second quarter when Purdy connected with Kittle for a pivotal touchdown, giving the 49ers a lead they would not relinquish.