In a dominating display, the San Francisco 49ers defeated the Arizona Cardinals 52-7 in Week 3 of the 2027 season. With this victory, the 49ers solidified their status as one of the league's top contenders, showcasing their offensive firepower and defensive prowess against a struggling Cardinals team. Brock Purdy was the standout performer for the 49ers, throwing for an impressive 339 yards and five touchdowns, connecting consistently with his receivers. KJ Duff emerged as his favorite target, racking up a staggering 292 receiving yards, while Mark Fletcher Jr. added to the onslaught with 194 rushing yards, contributing to a balanced and explosive offensive effort. Defensively, the 49ers were also impressive, with DJ Turner II snagging an interception that shifted momentum early in the game. The Cardinals struggled to find their rhythm against a relentless 49ers defense, which effectively stifled any attempts at a comeback. The turning point came when Purdy connected with Duff for a long touchdown in the second quarter, putting the game well out of reach and setting the stage for a commanding win.