The San Francisco 49ers held off the Miami Dolphins with a final score of 16-10 in a tightly contested Week 2 matchup of the 2026 season. With both teams looking to establish momentum early in the season, the 49ers managed to secure their first victory, showcasing their resilience on both sides of the ball. Brock Purdy led the charge for San Francisco, throwing for a crucial touchdown while managing the game effectively. Christian McCaffrey was a standout on the ground, racking up 110 rushing yards to keep the Dolphins' defense off balance. Meanwhile, Malik Willis of Miami put up impressive numbers with 230 passing yards, and Darius Slayton emerged as his go-to target, accumulating 113 receiving yards. Defensively, the 49ers made their mark with Marques Sigle leading the unit with seven tackles, while Renardo Green sealed the game with a pivotal interception. The turning point came in the fourth quarter when Green's pick halted a Dolphins drive, preserving the narrow lead and allowing San Francisco to run out the clock. Chop Robinson's two sacks for Miami kept the pressure on Purdy, but it was San Francisco's defensive resilience that ultimately secured the win.