In a commanding performance, the Arizona Cardinals topped the San Francisco 49ers 45-9 in Week 11 of the 2027 season, solidifying their playoff aspirations. The Cardinals came into this matchup looking to assert their dominance in the division, and they did just that with an impressive offensive display. Carson Beck led the charge for Arizona, throwing for 271 yards and two touchdowns, showcasing his ability to execute the game plan effectively. Supporting him was Trey Benson, who racked up 84 rushing yards, and Marvin Harrison Jr., who was a standout in the passing game with 99 receiving yards. Together, they propelled the Cardinals to an offensive explosion that left the 49ers struggling to keep pace. Defensively, the Cardinals made their mark as well, with Clev Lubin recording two sacks and Max Melton snagging an interception, contributing to the overall dominance of the team. The game's turning point came early in the second quarter when Melton's interception shifted momentum firmly in Arizona's favor, allowing them to build a lead that San Francisco could not recover from. Ultimately, the Cardinals' balanced attack on both sides of the ball proved too much for the 49ers to handle.