In a commanding performance, the San Francisco 49ers topped the Denver Broncos 49-28 in Week 4 of the 2026 season. With playoff aspirations on the line, the 49ers showcased their dominance at home, proving their mettle against a struggling Broncos squad. Brock Purdy was the standout for San Francisco, throwing for 344 yards and four touchdowns, consistently finding open receivers and orchestrating a potent offensive attack. Christian McCaffrey contributed significantly on the ground with 95 rushing yards, while De'Zhaun Stribling emerged as a favorite target, racking up 141 receiving yards and a touchdown. This dynamic trio played a crucial role in establishing the 49ers' offensive rhythm throughout the game. Defensively, the 49ers made their presence felt, with Renardo Green leading the team with nine tackles and Fred Warner snagging an interception. The game's turning point came in the second quarter when San Francisco scored two quick touchdowns, shifting momentum and leaving the Broncos reeling. The relentless pressure from the 49ers' defense stifled any comeback efforts from Denver, solidifying San Francisco's commanding win.