In a decisive Week 4 matchup of the 2026 season, the Denver Broncos cruised to a commanding 35-10 victory over the San Francisco 49ers. With this win, the Broncos continue to solidify their position in the league, showcasing their offensive firepower and defensive resilience against a struggling 49ers squad. Bo Nix was the star of the night for Denver, throwing for 232 yards and four touchdowns, effectively leading the charge through the air. Meanwhile, Jaylen Waddle emerged as a standout receiver, racking up an impressive 187 receiving yards, while RJ Harvey contributed a solid 74 rushing yards to keep the defense honest. The Broncos’ offensive display was both efficient and explosive, leaving the 49ers defense scrambling for answers. Defensively, the Broncos were equally impressive, with Brandon Jones leading the team with three total tackles. Talanoa Hufanga added pressure with a sack, while Patrick Surtain II's interception marked a crucial moment in the game, ensuring Denver's dominance throughout. The turning point came early in the second half when Surtain's pick set up another quick score, effectively putting the game out of reach for San Francisco.