In a decisive Week 10 matchup, the Seattle Seahawks triumphed over the San Francisco 49ers with a commanding score of 41-10. This victory solidifies Seattle's position as a frontrunner in the division, while the 49ers will need to regroup as they face increasing pressure in the playoff race. Quarterback Sam Darnold delivered a standout performance, throwing for an impressive 449 yards and four touchdowns, showcasing his ability to carve through the 49ers' defense. Jaxon Smith-Njigba was a key target, racking up 222 receiving yards, making him a significant threat throughout the game. Christian McCaffrey led the 49ers with 84 rushing yards but struggled to find the end zone amid Seattle's defensive effort. While the Seahawks' offense stole the spotlight, their defense played a critical role in the outcome as well. Dani Dennis-Sutton's pressure on the quarterback resulted in a sack, while Fred Warner's leadership for the 49ers was evident with his seven tackles and an interception. The turning point came late in the first half when Darnold connected for a 75-yard touchdown pass to Smith-Njigba, shifting momentum firmly in Seattle's favor and leaving the 49ers unable to recover.