In a decisive showdown, the San Francisco 49ers topped the Arizona Cardinals 46-16, solidifying their position as a dominant force in Week 3 of the 2026 season. With both teams seeking to build momentum, the 49ers showcased their prowess, leaving no doubt as to who would emerge victorious. Brock Purdy led the charge for San Francisco, throwing for 302 yards and three touchdowns, effectively distributing the ball to his playmakers. Christian McCaffrey was a force on the ground, rushing for 121 yards, while Mike Evans torched the secondary with 134 receiving yards, combining to create a powerful offensive display that kept the Cardinals on their heels. Defensively, the 49ers were equally impressive, with Renardo Green snagging an interception that shifted the momentum in San Francisco's favor. The turning point came in the second quarter when Green's pick set up another scoring drive, allowing the 49ers to take control. Though the Cardinals' Dadrion Taylor-Demerson led the game with seven tackles, it was the 49ers' defense that consistently stifled Arizona's efforts, ensuring a comfortable victory.