In a commanding performance, the Buffalo Bills topped the Detroit Lions 35-6 in Week 2 of the 2026 season. This victory not only secures Buffalo's strong start to the season but also underscores their dominance against a struggling Lions squad. C.J. Stroud led the charge for Buffalo, throwing for 162 yards and two touchdowns, showcasing his precision and poise in the pocket. Jahmyr Gibbs contributed significantly on the ground, racking up 91 rushing yards, while the Lions' Jakobi Meyers stood out for his team with 80 receiving yards, but it wasn't enough to close the gap. Defensively, the Bills were relentless, with Andrew Van Ginkel recording two sacks and Reed Blankenship snagging an interception to stifle any momentum from Detroit. The turning point of the game came in the second quarter when Buffalo's defense forced a turnover, allowing Stroud to capitalize with a quick touchdown drive, effectively putting the game out of reach for the Lions.