In a high-octane showdown, the Buffalo Bills topped the Detroit Lions 45-28 in Week 2 of the 2026 season, showcasing their offensive firepower. Both teams were looking to establish momentum early in the season, but it was the Bills who emerged victorious in this thrilling contest. Josh Allen was the star of the night for Buffalo, throwing for 251 yards and four touchdowns, effectively orchestrating the offense. Meanwhile, Jahmyr Gibbs put on a show for Detroit, racking up 174 rushing yards, and Jameson Williams added 100 receiving yards, keeping the Lions competitive until the final whistle. Defensively, the Bills made key plays that shifted the momentum, highlighted by C.J. Gardner-Johnson's interception, which stifled a potential scoring drive for Detroit. The turning point came late in the second quarter when Buffalo scored back-to-back touchdowns, creating a gap that the Lions couldn't close. Maxwell Hairston’s five tackles were instrumental in maintaining pressure, helping to seal the win for Buffalo.