In the opening week of the 2026 NFL season, the San Francisco 49ers topped the Los Angeles Rams with a final score of 31-20, kicking off their campaign with a strong performance. This matchup was crucial for both teams as they looked to establish their dominance early in the season. Jimmy Garoppolo led the charge for the 49ers, throwing for 219 yards and two touchdown passes, showcasing his effectiveness in the pocket. Raheem Mostert contributed significantly on the ground with 82 rushing yards, adding balance to San Francisco's offensive attack. Meanwhile, Cooper Kupp was the standout for the Rams, racking up 78 receiving yards but ultimately unable to push his team to victory. Defensively, the 49ers made impactful plays at key moments, highlighted by K'Waun Williams’ interception that shifted momentum back to San Francisco. D.J. Jones added to the defensive effort with a sack, putting pressure on the Rams' offense throughout the game. The turning point came in the second half when the 49ers' defense stifled a potential scoring drive from Los Angeles, allowing San Francisco to maintain control and secure the win.