In a decisive matchup, the San Francisco 49ers topped the Arizona Cardinals 27-7 in Week 6 of the 2027 season. With this victory, the 49ers solidify their position in the playoff race, looking to build momentum as the season progresses. The Cardinals, meanwhile, will need to regroup after a tough outing on the road. Brock Purdy was the standout performer for San Francisco, throwing for 268 yards and two touchdowns, showcasing his efficiency in the passing game. De'Zhaun Stribling emerged as a key target, racking up 142 receiving yards and providing a spark for the 49ers' offense. The combination of Purdy's accurate throws and Stribling's big-play ability kept the Cardinals' defense on its heels throughout the game. Defensively, the 49ers were dominant, highlighted by Fred Warner's two interceptions that turned the tide in their favor. Ephesians Prysock led the team with five tackles, while Jailin Walker contributed with a sack, applying consistent pressure on the Cardinals' quarterback. The turning point came in the second quarter when Warner's interception not only halted a potential scoring drive but also set up a touchdown that extended the 49ers' lead, ultimately sealing the game.