In a high-octane showdown, the Arizona Cardinals topped the San Francisco 49ers with a final score of 42-31 in Week 3 of the 2026 season. Both teams entered the game looking to solidify their standing in the division, but it was the Cardinals who emerged victorious, showcasing their offensive firepower. Arizona's offense was led by quarterback Joe Milton, who threw for three touchdowns and kept the chains moving with precision. Jeremiyah Love bolstered the ground game with an impressive 140 rushing yards, while Xavier Legette dominated through the air, racking up 183 receiving yards. This trio of offensive stars proved too much for the 49ers to handle. On the defensive side, the Cardinals made critical plays that ultimately swung the momentum in their favor. Karson Sharar's two sacks pressured San Francisco's quarterback, while Will Johnson's two interceptions provided crucial turnovers. The turning point came late in the third quarter when Johnson's second pick halted a promising San Francisco drive, allowing Arizona to extend their lead and maintain control until the final whistle.