In a dominant performance, the San Francisco 49ers defeated the Miami Dolphins 42-21 in Week 2 of the 2026 season. With both teams looking to establish momentum early in the year, the 49ers showcased their offensive firepower to secure the victory at home. Brock Purdy led the charge for San Francisco, throwing for three touchdowns and effectively managing the game. Meanwhile, Malik Willis put up impressive numbers for Miami, amassing 360 passing yards and keeping his team competitive. Greg Dulcich emerged as a standout receiver for the Dolphins, racking up 160 receiving yards, but it wasn’t enough to overcome the 49ers' scoring onslaught. Defensively, San Francisco's Charvarius Ward Sr. made a significant impact with two interceptions, disrupting Miami's offensive rhythm. Nick Bosa also contributed with 1.5 sacks, applying pressure that led to key turnovers. The turning point came in the second quarter when Purdy threw a touchdown pass to extend the lead, putting the Dolphins on their heels and allowing the 49ers to control the game from that point onward.