The San Francisco 49ers secured a decisive victory over the Arizona Cardinals, topping them 28-7 in Week 3 of the 2026 season. With this win, the 49ers continue to establish themselves as a formidable force early in the season, showcasing their offensive firepower and defensive prowess. Leading the charge for San Francisco was quarterback Brock Purdy, who threw for an impressive 250 yards and four touchdowns, demonstrating precision and poise in the pocket. He connected frequently with Mike Evans, who racked up 136 receiving yards, while Christian McCaffrey added a solid ground game with 82 rushing yards. This offensive trio was pivotal in establishing an early lead that the Cardinals could not overcome. Defensively, the 49ers were relentless, with Nick Bosa recording two sacks and Fred Warner adding an interception to stymie any hopes of a Cardinals comeback. The game's turning point came early in the second half when Bosa's sack led to a turnover on downs, allowing San Francisco to extend their lead and ultimately seal the game. Arizona struggled to find their rhythm, and the 49ers' defensive dominance was a key factor in their commanding win.