In a thrilling Week 4 matchup, the Denver Broncos topped the San Francisco 49ers with a commanding final score of 52-35. The victory puts the Broncos firmly in the mix as they look to establish dominance in the early stages of the 2026 season, while the 49ers aim to bounce back after this tough loss. Isiah Pacheco was the star of the show, racking up an impressive 349 rushing yards, showcasing his speed and power throughout the game. Brock Purdy led the 49ers with 205 passing yards and a touchdown, but it was not enough to keep pace with Denver's explosive offense. Ricky Pearsall added 73 receiving yards, providing a reliable target for Purdy as they tried to mount a comeback. Defensively, the Broncos made crucial plays that shifted momentum, highlighted by Talanoa Hufanga's two sacks and Sauce Gardner's interception. The turning point came when Gardner intercepted a pivotal pass in the second half, setting up a touchdown that extended Denver's lead and ultimately sealed the game. Nick Cross led the Broncos with four tackles, contributing to a defense that consistently pressured the 49ers and forced them into tough situations.