In a decisive Week 3 matchup, the Arizona Cardinals dominated the San Francisco 49ers, securing a commanding 45-7 victory. This win not only boosts the Cardinals’ momentum early in the 2026 season but also serves as a stark reminder of their offensive firepower and defensive prowess. Quarterback Jacoby Brissett led the charge for Arizona, throwing for 217 yards and two touchdowns, showcasing both precision and leadership. Running back Jeremiyah Love contributed significantly on the ground with 90 rushing yards, while Kendrick Bourne emerged as a reliable target, racking up 74 receiving yards. Together, they carved through the 49ers' defense, establishing an insurmountable lead. On the defensive side, the Cardinals were relentless, with Budda Baker making a game-changing impact by snagging two interceptions. Kaleb Proctor added to the pressure with a sack, consistently disrupting San Francisco's offensive rhythm. The game turned decisively in Arizona's favor early on, as a critical interception by Baker shifted the momentum completely, leading to a quick touchdown that set the tone for the rest of the contest.