In a thrilling opening week of the 2026 season, the Los Angeles Rams topped the San Francisco 49ers with a final score of 38-24. This victory sets the tone for the Rams as they look to establish themselves early in the NFC West. Matthew Stafford was the standout performer for the Rams, throwing for an impressive 352 yards and four touchdowns, showcasing his ability to command the offense effectively. Puka Nacua emerged as his favorite target, racking up a staggering 219 receiving yards, creating mismatches throughout the game. Meanwhile, Jahmyr Gibbs led the 49ers' rushing attack with 75 yards, but it wasn’t enough to keep pace with the Rams' explosive offense. Defensively, the Rams made crucial plays that shifted momentum in their favor. Trent McDuffie's interception proved pivotal, halting a potential scoring drive from the 49ers and contributing to the Rams' commanding lead. Yetur Gross-Matos also added pressure with a sack, limiting San Francisco's offensive options and helping the Rams secure a solid start to their season.