The Detroit Lions dominated the Buffalo Bills with a final score of 42-13, showcasing their offensive firepower in Week 2 of the 2026 season. This victory solidifies the Lions' early-season momentum while leaving the Bills searching for answers as they face a tough road ahead. Leading the charge for Detroit was Isaac TeSlaa, who lit up the field with 105 receiving yards, making crucial catches that propelled the Lions' scoring drives. Quarterback Jared Goff distributed the ball effectively, while Jahmyr Gibbs added 62 rushing yards to keep the chains moving and the defense on its heels. Although Josh Allen of the Bills threw for 190 yards and a touchdown, it was not enough to keep pace with Detroit's explosive offense. Defensively, the Lions were relentless, with Jack Campbell recording 1.5 sacks to pressure Allen throughout the game. D.J. Reed's interception marked a pivotal moment, halting a potential Buffalo scoring drive and further shifting momentum in favor of Detroit. The Lions' ability to stifle the Bills' offense ultimately proved decisive, allowing them to maintain control and secure a commanding victory.