In a thrilling Week 3 matchup, the San Francisco 49ers narrowly defeated the Arizona Cardinals with a final score of 38-28. Both teams entered the game looking for a critical win to boost their standing in the competitive NFC West, but it was the 49ers who came away with the victory at home. Jacoby Brissett showcased his arm talent for the Cardinals, throwing for 278 yards and three touchdowns, while wide receiver Trey McBride pulled in 130 receiving yards, making significant contributions throughout the game. On the ground, the 49ers leaned on Omarion Hampton, who rushed for an impressive 119 yards, consistently finding ways to break through the Cardinals' defensive line and keep the chains moving. Defensively, the 49ers made key plays that shifted momentum in their favor. Mykel Williams dominated up front with two sacks, applying pressure on Brissett and disrupting Arizona's offensive rhythm. The turning point came late in the fourth quarter when Fred Warner snagged an interception, sealing the deal for San Francisco and ensuring their hard-fought victory.