The Denver Broncos decisively topped the San Francisco 49ers with a final score of 52-20 in Week 4 of the 2026 season. This victory not only boosts the Broncos' confidence but also solidifies their standing as a formidable contender in the league. The 49ers, on the other hand, will need to regroup after this tough defeat. Quarterback Bo Nix was the standout performer for Denver, throwing for 279 yards and three touchdowns. J.K. Dobbins made his mark on the ground, rushing for 113 yards, while Courtland Sutton showcased his receiving prowess with 124 yards. Together, they fueled a potent Broncos offense that overwhelmed the 49ers’ defense throughout the game. Defensively, the Broncos were equally impressive, with Nik Bonitto leading the charge with two sacks, consistently applying pressure on the 49ers’ offense. A pivotal moment came when Denver's defense forced a key turnover, which shifted momentum squarely in their favor. The combination of offensive firepower and defensive strength proved too much for San Francisco to overcome, sealing a commanding victory for the Broncos.